Journal of Veterinary Science and Animal Welfare

Healing of wound involves a series of overlapping phases, including homeostasis, inflammation, proliferation, and remodeling. The inflammation is accompanied by edema, pain, redness and leukocytic infiltration as neutrophils, macrophages and fibroblasts that were considered as minor sources of the cytokine[1,2]. The healing process in full-thickness wounds includes coagulation, inflammation, formation of tissue, and remodeling[3]. The inflammatory phase extends from 1 5 days after injury by migration and accumulation of cells in the wound with predominating of neutrophils in the early hours of inflammation. Finally, the re-epithelialization start at the edges of the wound as early as 24 hours post injury, while wound granulation begins 5 days after injury to re-establish the epidermis and dermis in1 Department of Anesthesiology, Vetsuisse Faculty, University of Zurich, Switzerland 2 Surgery, Anesthesiology and Radiology Department, Faculty of Veterinary Medicine, Mansoura University, Egypt 3 Faculty of Science, Medical Physics Department, King Abdulaziz University, Kingdom of Saudi Arabia